An article in the February 2011 Archives of General Psychiatry, “Long-term Antipsychotic Treatment and Brain Volumes” by Ho, Andreasen, et al. describes a study that points to antipsychotic drugs as a major cause of brain shrinkage. The study found that over 7 to 14 years, “More antipsychotic drug treatment, including duration and intensity, was linked to greater declines in brain volume. Severity of disease, alcohol and illegal drug use had no effect.”

ho-andreasen-201102-brain-volume.pdf — PDF document, 239Kb